![]() (v) The dynamics of autocatalytic self-organization are facilitated by a multiplicity of weak interactions, such as hydrogen bonding, within and between macromolecular assemblies. (iv) Dynamic self-assembly of prebiotic organic matter is driven by hydrophobic tension between water and amphiphilic building blocks, such as aggregating peptides from non-polar amino acids and base stacking in nucleic acids. ![]() (iii) Environmental energy gradients are exploited progressively, approaching maximum interactive structure and minimum dissipation. (ii) Energetic ‘charging’ of the prebiosphere must precede the emergence of biological organization. (i) Connecting life’s origins and complex organization to a preexisting physical world demands a thermodynamically sound transition. Several integrative concepts are worth remembering from Wicken’s legacy. ![]() Wicken (1942–2002)-the evolutionarily minded biochemist, who in the 1970/80s strived for a synthesis of biological and physical theories to fathom the tentative origins of life.
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